Interesting question! I’m not sure whether we know the exact answer to this. In cancers like lung or liver cancer, many of your white blood cells will become activated and try to fight the cancer. Some cancers affect the white blood cells themselves, and then all of the white cells could be damaged.
Yes it is an interesting one. I had to think about it. If the cancer is small, it may only be having a local effect and therefore not change the immune cells. But once it spreads and gets really large, it can release inflammation chemicals (cytokines) which can really alter the immune system.
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